4954-Chen, Hanying

Hanying Chen, MD

Associate Research Professor of Medical & Molecular Genetics

Address
IB 252
MMGE
IN
Indianapolis, IN
PubMed:

Bio

Hanying Chen received his M.D. from Tongji Medical University in Wuhan, China, and joined the Indiana University Herman B Wells Pediatric Research Center in 2000, where he focused on cardiac development and congenital heart disease. In 2014, he became the manager of the Indiana University Mouse Transgenic Core. He introduced CRISPR/Cas9-based gene editing technology to the core, providing technical support for mouse gene manipulation to all laboratories at Indiana University and across the country.

Key Publications

Kent E. Williams, Yi Zou, Bin Qiu, Tatsuyoshi Kono, Changyong Guo, Dawn Garcia, Hanying Chen, Tamara Graves, Zhao Lai, Carmella Evans-Molina, Yao-Ying Ma, Suthat Liangpunsakul, Weidong Yong, Tiebing Liang *. Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol. Cells. 2023 Dec 31;13(1):89. doi: 10.3390/cells13010089

Cassidy AM, Thomas DB, Kuliyev E, Chen H, Pelletier S. One-step generation of a conditional allele in mice using a short artificial intron. Heliyon. 2022 Dec 24;8(12):e12630. doi: 10.1016

Cassidy AM, Kuliyev E, Thomas DB, Chen H, Pelletier S. Dissecting protein function in vivo: Engineering allelic series in mice using CRISPR-Cas9 technology. Methods Enzymol. 2022; Epub 2022 Apr 13.

Liu J, Zhang Y, Han L, Guo S, Wu S, Doud EH, Wang C, Chen H, Rubart-von der Lohe M, Wan J, Yang L. Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes. Stem Cell Reports. 2022 Mar 8;17(3):522-537. doi: 10.1016/j.stemcr.2022.01.014

Zhang W, Conway SJ, Liu Y, Snider P, Chen H, Gao H, Liu Y, Isidan K, Lopez KJ, Campana G, Li P, Ekser B, Francis H, Shou W, Kubal C. Heterogeneity of Hepatic Stellate Cells in Fibrogenesis of the Liver: Insights from Single-Cell Transcriptomic Analysis in Liver Injury. Cells. 2021 Aug 19;10(8):2129. doi: 10.3390/cells10082129.

Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R,… Miano JM, Burgio G. Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation". Genome Biol. 2021 Apr 7;22(1):99. doi: 10.1186/s13059-021-02320-3

Qu X, Liu Y, Cao D, Chen J, Liu Z, Ji H, Chen Y, Zhang W, Zhu P, Xiao D, Li X, Shou W, Chen H. BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways. J Biol Chem. 2019 Dec 27;294(52):19877-19888.

Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R,… Miano JM, Burgio G. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 2019 Aug 26; 20(1):171.

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