Zhihong(Joe) Yang, PhD
Associate Professor of Medicine
- Phone
- (317) 988-3388
- Address
-
VA
GAST
IN
Indianapolis, IN - PubMed:
-
Bio
Dr. Yang is an Associate Professor in the Division of Gastroenterology and Hepatology at the Indiana University School of Medicine. His research focuses on the pathogenesis of alcohol-associated liver disease (ALD), with particular emphasis on non-coding RNAs, lipid metabolism, and RNA alternative splicing.
Dr. Yang joined IU School of Medicine in 2018 as a tenure-track Assistant Professor and was promoted to Associate Professor with tenure in 2025. He has received multiple awards and research grants, including a Mentored Research Scientist Development Award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and early career development awards from the Central Society for Clinical and Translational Research (CSCTR), as well as several internal funding awards and a recent R01 to uncover how RNA splicing contributes to ALD progression. His long-term goal is to identify novel diagnostic markers and therapeutic targets to deepen our understanding of the molecular mechanisms driving ALD and other chronic liver diseases.
| Year | Degree | Institution |
|---|---|---|
| 2009 | PhD | Beijing Institute of Biotechnology |
| 2005 | MS | Henan Agricultural University |
| 2002 | BS | Henan Agricultural University |
Silencing FAF2 mitigates alcohol-induced hepatic steatosis by modulating lipolysis and PCSK9 pathway.
Huda N; Kusumanchi P; Jiang Y; Gao H; Thoudam T; Zeng G; Skill NJ; Sun Z; Liangpunsakul S; Ma J; Yang Z; Hepatology communications 2025 Feb 19
Huda N; Kusumanchi P; Jiang Y; Gao H; Thoudam T; Zeng G; Skill NJ; Sun Z; Liangpunsakul S; Ma J; Yang Z; Hepatology communications 2025 Feb 19
LncRNA H19 promoted alcohol-associated liver disease through dysregulation of alternative splicing and methionine metabolism.
Yang Z; Jiang Y; Ma J; Wang L; Han S; Huda N; Kusumanchi P; Gao H; Thoudam T; Sun Z; Liangpunsakul S; Hepatology (Baltimore, Md.) 2024 Aug 29
Yang Z; Jiang Y; Ma J; Wang L; Han S; Huda N; Kusumanchi P; Gao H; Thoudam T; Sun Z; Liangpunsakul S; Hepatology (Baltimore, Md.) 2024 Aug 29
HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis.
Huang Y; Liangpunsakul S; Rudraiah S; Ma J; Keshipeddy SK; Wright D; Costa A; Burgess D; Zhang Y; Huda N; Wang L; Yang Z; Hepatology communications 2023 Nov 6
Huang Y; Liangpunsakul S; Rudraiah S; Ma J; Keshipeddy SK; Wright D; Costa A; Burgess D; Zhang Y; Huda N; Wang L; Yang Z; Hepatology communications 2023 Nov 6
The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease?
Yang Z; Ding WX; Hepatology (Baltimore, Md.) 2023 May 16
Yang Z; Ding WX; Hepatology (Baltimore, Md.) 2023 May 16
Transcriptomic Analysis Reveals the Messenger RNAs Responsible for the Progression of Alcoholic Cirrhosis.
Yang Z; Han S; Zhang T; Kusumanchi P; Huda N; Tyler K; Chandler K; Skill NJ; Tu W; Shan M; Jiang Y; Maiers JL; Perez K; Ma J; Liangpunsakul S; Hepatology communications 2022 Feb 8
Yang Z; Han S; Zhang T; Kusumanchi P; Huda N; Tyler K; Chandler K; Skill NJ; Tu W; Shan M; Jiang Y; Maiers JL; Perez K; Ma J; Liangpunsakul S; Hepatology communications 2022 Feb 8
Transcriptomic Analysis Reveals the MicroRNAs Responsible for Liver Regeneration Associated With Mortality in Alcohol-Associated Hepatitis.
Yang Z; Zhang T; Kusumanchi P; Tang Q; Sun Z; Radaeva S; Peiffer B; Shah VH; Kamath P; Gores GJ; Sanyal A; Chalasani N; Jiang Y; Huda N; Ma J; Liangpunsakul S; Hepatology (Baltimore, Md.) 2021 Jul 26
Yang Z; Zhang T; Kusumanchi P; Tang Q; Sun Z; Radaeva S; Peiffer B; Shah VH; Kamath P; Gores GJ; Sanyal A; Chalasani N; Jiang Y; Huda N; Ma J; Liangpunsakul S; Hepatology (Baltimore, Md.) 2021 Jul 26
The role of SHP/REV-ERBa/CYP4A axis in the pathogenesis of alcohol-associated liver disease.
Yang Z; Smalling RV; Huang Y; Jiang Y; Kusumanchi P; Bogaert W; Wang L; Delker DA; Skill NJ; Han S; Zhang T; Ma J; Huda N; Liangpunsakul S; JCI insight 2021 Aug 23
Yang Z; Smalling RV; Huang Y; Jiang Y; Kusumanchi P; Bogaert W; Wang L; Delker DA; Skill NJ; Han S; Zhang T; Ma J; Huda N; Liangpunsakul S; JCI insight 2021 Aug 23
Long noncoding RNA H19 - a new player in the pathogenesis of liver diseases.
Yang Z; Zhang T; Han S; Kusumanchi P; Huda N; Jiang Y; Liangpunsakul S; Translational research : the journal of laboratory and clinical medicine 2020 Nov 20
Yang Z; Zhang T; Han S; Kusumanchi P; Huda N; Jiang Y; Liangpunsakul S; Translational research : the journal of laboratory and clinical medicine 2020 Nov 20
Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease.
Jiang Y; Zhang T; Kusumanchi P; Han S; Yang Z; Liangpunsakul S; Biomedicines 2020 Mar 4
Jiang Y; Zhang T; Kusumanchi P; Han S; Yang Z; Liangpunsakul S; Biomedicines 2020 Mar 4
Role of microRNA-7 in liver diseases: a comprehensive review of the mechanisms and therapeutic applications.
Han S; Zhang T; Kusumanchi P; Huda N; Jiang Y; Liangpunsakul S; Yang Z; Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2020 Aug 24
Han S; Zhang T; Kusumanchi P; Huda N; Jiang Y; Liangpunsakul S; Yang Z; Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2020 Aug 24
Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2<sup>-/-</sup> mice.
Meadows V; Kennedy L; Hargrove L; Demieville J; Meng F; Virani S; Reinhart E; Kyritsi K; Invernizzi P; Yang Z; Wu N; Liangpunsakul S; Alpini G; Francis H; Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 13
Meadows V; Kennedy L; Hargrove L; Demieville J; Meng F; Virani S; Reinhart E; Kyritsi K; Invernizzi P; Yang Z; Wu N; Liangpunsakul S; Alpini G; Francis H; Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 13
Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2<sup>-/-</sup> mouse model of primary sclerosing cholangitis (PSC).
Zhou T; Kyritsi K; Wu N; Francis H; Yang Z; Chen L; O'Brien A; Kennedy L; Ceci L; Meadows V; Kusumanchi P; Wu C; Baiocchi L; Skill NJ; Saxena R; Sybenga A; Xie L; Liangpunsakul S; Meng F; Alpini G; Glaser S; EBioMedicine 2019 Sep 12
Zhou T; Kyritsi K; Wu N; Francis H; Yang Z; Chen L; O'Brien A; Kennedy L; Ceci L; Meadows V; Kusumanchi P; Wu C; Baiocchi L; Skill NJ; Saxena R; Sybenga A; Xie L; Liangpunsakul S; Meng F; Alpini G; Glaser S; EBioMedicine 2019 Sep 12
Possible application of melatonin treatment in human diseases of the biliary tract.
Baiocchi L; Zhou T; Liangpunsakul S; Ilaria L; Milana M; Meng F; Kennedy L; Kusumanchi P; Yang Z; Ceci L; Glaser S; Francis H; Alpini G; American journal of physiology. Gastrointestinal and liver physiology 2019 Sep 11
Baiocchi L; Zhou T; Liangpunsakul S; Ilaria L; Milana M; Meng F; Kennedy L; Kusumanchi P; Yang Z; Ceci L; Glaser S; Francis H; Alpini G; American journal of physiology. Gastrointestinal and liver physiology 2019 Sep 11
Intercellular Communication between Hepatic Cells in Liver Diseases.
Sato K; Kennedy L; Liangpunsakul S; Kusumanchi P; Yang Z; Meng F; Glaser S; Francis H; Alpini G; International journal of molecular sciences 2019 May 2
Sato K; Kennedy L; Liangpunsakul S; Kusumanchi P; Yang Z; Meng F; Glaser S; Francis H; Alpini G; International journal of molecular sciences 2019 May 2
Serum Metabolomic Profiling Identifies Key Metabolic Signatures Associated With Pathogenesis of Alcoholic Liver Disease in Humans.
Yang Z; Kusumanchi P; Ross RA; Heathers L; Chandler K; Oshodi A; Thoudam T; Li F; Wang L; Liangpunsakul S; Hepatology communications 2019 Feb 20
Yang Z; Kusumanchi P; Ross RA; Heathers L; Chandler K; Oshodi A; Thoudam T; Li F; Wang L; Liangpunsakul S; Hepatology communications 2019 Feb 20
H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis.
Zhang L; Yang Z; Huang W; Wu J; Cell death & disease 2019 Feb 18
Zhang L; Yang Z; Huang W; Wu J; Cell death & disease 2019 Feb 18
Looking for patient care?
To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.